Results from a late-breaking study showed that abnormalities in the proteome are a valuable biomarker to predict the development of rheumatoid arthritis (RA), in addition to elevated anti-citrullinated protein antibodies (ACPA).
Although individuals with elevated ACPA have a higher risk to develop RA, most will not do so. Therefore, an additional biomarker for the prediction of RA is urgently needed. Dr Liam O´Neil (University of Manitoba, Canada) evaluated whether abnormalities in the serum proteome may allow for a better prediction of future disease onset. Using SOMAscan array, quantitative levels of 1,307 proteins were determined in serum samples from 17 first-degree relatives of RA patients who developed inflammatory arthritis synovitis after having been followed prospectively for a mean of 3.2 years. All 17 subjects were ACPA+ at time of inflammatory arthritis diagnosis. In each individual, 2 samples were assessed: 1 at the time of inflammatory arthri...
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Table of Contents: ACR 2019
Spotlight on Rheumatoid Arthritis
What is Hot in Systemic Lupus Erythematosus
Spondyloarthritis – the Beat Goes On
Osteoarthritis – State-of-the-Art
Reproductive Issues in Rheumatic Disease
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