Treatment with hydroxychloroquine significantly reduced the recurrence rate of congenital heart block (CHB) for children of mothers with a previous child affected .
CHB is one of the clinical manifestations of a neonatal lupus syndrome . It is associated with a 17.5% mortality and 70% requirement of permanent pacing . The disease is induced by a placental transport of maternal anti-SSA/Ro antibodies . Women carrying these antibodies may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth .
“CHB affects an estimated 2% of pregnancies among women who have anti-SSA/Ro antibodies who have never been pregnant or have never had an affected child. It appears maternal health accompanying the production of the candidate autoantibodies is not a risk factor for foetal disease, since many mothers whose foetuses develop cardiac injury are asymptomatic and ...
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