Emapalumab, an interferon gamma (IFNγ)-blocking monoclonal antibody, has shown efficacy and safety in patients with macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (SJIA)
MAS is a rare, systemic life-threatening disorder characterised by uncontrolled hyperinflammation which may develop on a background of rheumatic diseases such as SJIA. It is classified as a secondary form of hemophagocytic lymphohistiocytosis (HLH) and is caused by excessive activation and expansion of T cells and macrophages. In recent years, evidence has shown uncontrolled overproduction of IFNγ as a major driver of hyperinflammation and hypercytokinaemia in diseases such as MAS and HLH. Emapalumab is a monoclonal antibody that binds to and neutralises interferon gamma (IFNγ).
Dr Fabrizio De Benedetti et al. (Ospedale Pediatrico Bambino Gesù, Italy) initiated a pilot study which aimed to assess the pharmacokinetics, efficacy, and safety of...
please login to read the entire article:
You need to register to read the entire article, please do so now.
« Peficitinib Likely Efficacious and Safe Next Article
Filgotinib Is Efficacious and Safe in PsA »
Table of Contents: EULAR 2019
Osteoarthritis and Osteoporosis
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.