Home > Rheumatology > EULAR 2019 > Miscellaneous > Emapalumab in Patients with Macrophage Activation Syndrome

Emapalumab in Patients with Macrophage Activation Syndrome

Presented By
Dr Fabrizio De Benedetti, Ospedale Pediatrico Bambino Gesù, Italy
Conference
EULAR 2019

Emapalumab, an interferon gamma (IFNγ)-blocking monoclonal antibody, has shown efficacy and safety in patients with macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (SJIA)

MAS is a rare, systemic life-threatening disorder characterised by uncontrolled hyperinflammation which may develop on a background of rheumatic diseases such as SJIA. It is classified as a secondary form of hemophagocytic lymphohistiocytosis (HLH) and is caused by excessive activation and expansion of T cells and macrophages. In recent years, evidence has shown uncontrolled overproduction of IFNγ as a major driver of hyperinflammation and hypercytokinaemia in diseases such as MAS and HLH. Emapalumab is a monoclonal antibody that binds to and neutralises interferon gamma (IFNγ).

Dr Fabrizio De Benedetti et al. (Ospedale Pediatrico Bambino Gesù, Italy) initiated a pilot study which aimed to assess the pharmacokinetics, efficacy, and safety of...



please login to read the entire article:


You need to register to read the entire article, please do so now.





Posted on