In his state-of-the-art lecture, Prof. Leendert Looijenga (Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands) discussed the connection between infertility and testicular cancer . The molecular associations were reviewed as well as putative causality.
Testicular germ cell tumours (TGCTs) display a tremendous variety of morphologic elements, often in mixed pathologies. Generally, TGCTs are classified as either germ cell neoplasia in situ (GCNIS), or non-GCNIS-associated TGCTs. Most malignant TGCTs originate from GCNIS. Molecular and genetic studies have highlighted 7 types of TGCTs, which can also be understood within terms of developmental processes.
Diagnosis, treating, and follow-up of TGCTs relies on understanding of the biological drivers of the disease, yet little is really known. TGCTs originate from GCNIS precursors, which are characterised by expression of the markers OCT4, SOX17, NANOG, as well as TSPY, and cKIT and ...
please login to read the entire article:
You need to register to read the entire article, please do so now.
« Peyronie’s disease: surgical options Next Article
32% more men complain of reduced sex drive in 2019 versus 2009 »
Table of Contents: EAU 2020
Surgical Techniques and Safety
Prostate Cancer & Imaging
BPH & LUTS
Testis Cancer & Andrology
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.