In Peyronie’s disease (PD) two abstracts, one from Italy and one from the US (Gocci et al., and El-Khatib et al., respectively), reported substantial efficacy of intralesional collagenase injection in atypical or hourglass PD curvatures and ventral deformities.
While the initial studies were performed in typical PD with dorsal curvature , the Italian study demonstrated improvement of >20 degrees in 57% of their cohort; whereas in the US study 90% patients had an improvement of >20 degrees. Both studies convincingly showed that, for atypical PD patients, injection of this therapy seems to confer benefit and it can be used to avoid surgery in these cases. In more news about PD, we saw some exciting basic research from Dr Uros Milenkovic and colleagues (Catholic University Leuven, Belgium) who performed state-of-the-art RNA sequencing of the fibrotic plaques from PD. To their surprise, despite the fact that all plaques were taken from patients in the...
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