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Benefits of chest CT screening

The 10-year follow-up in the population-based NELSON trial showed that CT screening of high-risk men reduces lung cancer death rates by 26% (95% CI 9-41%). In a smaller subset of women, the reduction was even larger. Prof. Harry de Koning (Erasmus Medical Center, the Netherlands) presented the outcomes [8].

The NELSON trial is not the first large study to show a survival benefit with population-based lung cancer screening. The original landmark study, the National Lung Screening Trial (NLST), was conducted in the United States in 2011 and demonstrated a 20% relative reduction in lung cancer deaths for annual screening with low-dose CT over 3 years vs chest radiography [9].

The NELSON study, conducted in the Netherlands and Belgium, used nodule volume management for referral. It was designed to show a 25% reduction in lung cancer in males at the 10-year follow-up. The trial enrolled 15,822 subjects aged 50-74 years. In the overall cohort, the mean number of pack-year...



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