Home > Guselkumab shows good long-term efficacy in psoriasis patients with and without arthritis

Guselkumab shows good long-term efficacy in psoriasis patients with and without arthritis

A pooled analysis of 2 ongoing phase 3 trials confirmed durable treatment results for the IL-23 blocker guselkumab in moderate-to-severe psoriasis over 3 years: about 80% of patients gained a PASI 90 response after this time, independent of their psoriatic arthritis status at baseline.

Guselkumab is a fully human monoclonal antibody that acts as a blocker of IL-23. The ongoing pivotal phase 3 trials VOYAGE 1 and 2 have demonstrated significant efficacy of guselkumab for the treatment of moderate-to-severe plaque psoriasis in comparison with an active comparator and placebo. The current investigation analysed pooled data from VOYAGE 1 and 2 with regard to long-term efficacy in patients with or without psoriatic arthritis (PsA) [1].

In VOYAGE 1, over 800 patients were treated in 3 different groups. They either received 100 mg guselkumab at week 0, 4, 12, followed by further doses every 8 weeks, or placebo at week 0, 4, 12 followed by GUS at week 16, 2...



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