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Reduced BCG frequency, faster NMIBC recurrence

Reduction in the frequency of Bacillus Calmette-Guérin (BCG) vaccine instillations during induction and maintenance treatment for non-muscle invasive bladder cancer (NMIBC) results in earlier disease recurrence relative to a standard instillation schedule.

Prof. Marc-Oliver Grimm (University Hospital Jena, Germany) presented a post-hoc analysis of the recurrence risk in patients with high-grade NMIBC in the randomised phase 3 NIMBUS trial, which was run by the EAU Research Foundation [1]. Prof. Grimm explained that, given the BCG shortage and the known BCG-associated toxicities, NIMBUS set out to investigate whether a reduced frequency of BCG instillations during induction and maintenance would result in non-inferior clinical efficacy, with potentially fewer adverse events, as well as reduced inconvenience and cost. The primary endpoint was time to first recurrence. Key ...



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