Home > Dermatology > AAD 2018 > Alopecia Areata > A glimpse into the future

A glimpse into the future

Presented By
Prof. Wilma Bergfeld, Cleveland Clinic, USA
Conference
AAD 2018
Alopecia areata (AA) is a chronic relapsing inflammatory disorder characterised by non-scarring hair loss on the scalp and/or body. As Prof. Wilma Bergfeld of the Cleveland Clinic indicated, in healthy subjects there is an immune privilege of the hair follicle [1]. A loss of this immune privilege leads to AA. Genome-wide association studies implicated ligands for the Natural Killer Group 2D (NKG2D) receptor (a product of the KLRK1 gene) in disease pathogenesis [2]. In a murine model of AA, a type I cytotoxic pathway has been demonstrated as responsible for the disease state, with NKG2D-expressing CD8+ cytolytic T-lymphocytes necessary for the induction of the disease. Upregulation of IL-15 in the outer root sheath of the hair follicle activates cytolytic T-lymphocytes, which in turn produce Interferon (IFN)γ, leading to activation of the hair follicle and upregulation of IL-15, NKG2D ligands, and major histocompatibility complex (MHC) molecules, all of which target the hai...


Please login to read the full text of the article.


If you have no account yet, please register now.





Posted on