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Possible role of brivaracetam in controlling acute seizures


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Conference
AAN 2019
In an exploratory trial, efficacy and safety of brivaracetam and lorazepam for controlling acute seizures were compared. The similar efficacy suggests a possible role of brivaracetam in this setting [1]. The study was designed as a phase 2, open-label, randomised, parallel-group, active-controlled proof-of-concept trial. Participants were adult patients admitted to an Epilepsy Monitoring Unit (EMU) in Birmingham, USA. They were randomised 1:1:1 to single-dose bolus intravenous lorazepam, brivaracetam 100 mg (BRV100), or brivaracetam 200 mg (BRV200), which was administered when a seizure required intervention. The primary efficacy outcome was time to next seizure or use of rescue medication. Of 45 randomised patients who received trial medication for a qualifying seizure, 11 (24.4%) had a seizure within 12 hours (lorazepam n=5, BRV100 n=3, BRV200n =3), suggesting similar efficacy across treatments. Most patients were seizure-free at 12 hours (lorazep...


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