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New sickle cell drug voxelotor boosts levels of haemoglobin

Presented By
Dr Jo Howard, King’s College London, United Kingdom
EHA 2019
Phase 3, HOPE
Results from the randomised, placebo-controlled, phase 3 Hemoglobin Oxygen Affinity Modulation to Inhibit HbS Polymerization (HOPE) trial of voxelotor in adults and adolescents with sickle cell disease showed promising effects on anaemia and haemolysis in roughly 60% of patients included [1]. As well as being presented at the EHA meeting, the data were simultaneously published in the New England Journal of Medicine [2]. Dr Jo Howard (King’s College London, United Kingdom) presented new data from the late-stage HOPE trial, which showed that voxelotor, a new treatment for sickle cell disease (SCD), significantly improves anaemia and haemolysis, and provides strong evidence that voxelotor has the potential to be a disease-modifying treatment that could prevent chronic organ damage. SCD is a genetic blood disorder that affects millions worldwide and can cause ...

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