Home > Haematology > EHA 2019 > Benign Haematology > Haematopoietic stem cell transplantation improves stroke risk in children with sickle cell anaemia

Haematopoietic stem cell transplantation improves stroke risk in children with sickle cell anaemia

Presented By
Dr Francoise Bernaudin, Intercommunal Hospital Center de Créteil, France
Conference
EHA 2019
Trial
DREPAGREFFE
Matched sibling donor stem cell transplantation (MSD-HSCT) was associated with lower transcranial doppler velocities (TCDs) at 1 year compared with chronic transfusions. Furthermore, MSD-HSCT was also associated with changes in highest TCDs at 3 years, normalisation rate at 1 year, and ferritin levels at 1 and 3 years [1]. In the late-breaking plenary session, Dr Francoise Bernaudin (Intercommunal Hospital Center de Créteil, France) presented their study data showing that increased TCD in children with sickle cell anaemia (SCA) is associated with an increased risk of ischaemic stroke, stenosis, and silent cerebral infarcts. Previous studies have identified the pivotal role of chronic transfusions in reducing stroke risk, while newer studies have considered other preventive approaches such as hydroxyurea or MSD-HSCT. The DREPAGREFFE study is a nonrandomised, control...


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