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Haematopoietic stem cells can sense tissue damage in the gut

Presented By
Dr Hitoshi Takizawa, Kumamoto University, Japan
EHA 2019
In the late-breaking oral session, Dr Hitoshi Takizawa (Kumamoto University, Japan) presented their study investigating how intestinal damage results in bone marrow haematopoiesis induction of haematopoietic stem cell (HSC) expansion followed by directional multipotent progenitor (MPP) migration to inflamed lymphoid tissues and generation of myeloid cells specialised for intestinal tissue repair [1]. Haematopoietic stem cells (HSCs) sustain lifelong haematopoiesis, while lineage-restricted progenitors actively divide and mainly contribute to daily haematopoiesis. Haematopoietic challenges such as inflammation or infection activate HSCs to self-renew. Systemic challenge of gram-negative bacteria directly activates dormant HSCs to proliferate and impairs their competitive fitness via Toll-like receptor (TLR)-4 signalling [2]. To test their hypothesis that progenitor cells (HSPCs) can sense tissue damage signals derived from distal organs such as the gut, and...

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