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Neuroinflammatory pathways as biomarkers and treatment targets

Presented By
Prof. Annamaria Vezzani, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Italy
Conference
EAN 2019
The important role of neuroinflammation in epilepsy featured in a plenary presentation by Prof. Annamaria Vezzani (Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Italy) [1]. About 30% of epilepsy patients are not seizure-free, despite the introduction of 20-30 new anti-epileptic drugs over the past 30 years. Prof. Vezzani argued that the identification of the pathogenic mechanisms of epileptogenesis will allow the design of novel treatments which are apt to prevent or reduce the generation of epileptic seizures. Neuroinflammation is a maladaptive brain response commonly ignited in human epileptogenic brain regions and is clearly involved in animal models of epilepsy, Prof. Vezzani explained. Experimental studies in animal models showed that -if not adequately controlled- neuroinflammation is involved in the pathogenesis of seizures, neuronal cell loss, and neurological comorbidities. Neuroinflammation has now been related to several types of human ...


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