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Panel of inflammation-associated microRNAs as epilepsy biomarker

EAN 2019
The identification of epilepsy biomarkers has represented one of the most significantly growing fields of study in recent years. A panel of 3 circulating microRNAs (miRs) with promising value as biomarker for genetic generalised epilepsy (GGE) was reported [1]. Several genome-wide studies in both animals and patients have demonstrated a dysregulation on the expression profile of miRs in epilepsy, with a focus on miRs associated with inflammation. In the reported study, researchers characterised circulating inflammation-associated miR-146a, miR-155, and miR-132 expression in 79 GGE patients and 67 healthy individuals. Serum levels of miR-146a and miR-155 were significantly upregulated compared with controls (3.13-fold and 6.05-fold, respectively). Combining miR-146a, miR-155, and miR-132 circulating levels increased biomarker performance to discriminate GGE patients from controls with an area under the curve (AUC) of 0.85, with 80% specificity and 73% sensi...

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