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Prognostic blood and MRI biomarkers

EAN 2019
In a Norwegian study, serum vitamin D levels were found to predict the long-term disease course of MS. Higher 25-hydroxy-vitamin D (25-OH-D) levels were associated with lower long-term disability in MS [1]. Neurofilament light chain (NfL) was found to correlate with cognitive impairment [2], while patients at higher risk of secondary progressive MS had more severe early brain atrophy [3]. Over a period of 2 years, serum levels of 25-OH-D were measured 9 times in 88 relapsing-remitting MS patients included in a randomised trial of omega 3 fatty acids (the OFAMS study). In 92% of participants, the expanded disability status scale (EDSS) could be assessed 10 years later [1]. The overall mean 25-OH-D levels in the baseline period was 74.0. The median EDSS score increased from 2.0 at baseline to 2.5 at follow-up. Higher 25-OH-D was associated with significantly lower disability progression 10 years later. Change in EDSS score per 20-unit increase in 25-OH-D was...

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