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Autologous haematopoietic stem cell transplantation

Presented By
Dr Alice Mariottini, Careggi University Hospital, Italy
EAN 2019
Phase 3, MIST
Autologous haematopoietic stem cell transplantation (aHSCT) is a promising treatment for aggressive refractory relapsing-remitting MS, as was illustrated in a workshop; it may however be effective in the progressive phase as well. Stabilisation of disability progression was observed in 75% of the patients and normalisation of brain atrophy in 35%, respectively [1]. A focused workshop was dedicated to aHSCT in relapsing-remitting MS. A meta-analysis of HSCT-studies from 1995 to 2016 showed that transplant-related mortality had dropped substantially over 20 years [2]. Patients with aggressive RRMS who have not yet accumulated a high level of disability, had the most favourable benefit-risk profile for this treatment. The pooled proportion of patients with NEDA was 67% after 5 years and almost 50% after 10 years. At the same workshop results from the phase 3 MIST trial were presented. In this randomised trial, nonmyeloablative HSCT treatment was compar...

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