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Thrombo-inflammation during ischaemia/reperfusion

Presented By
Prof. Guido Stoll, University of Würzburg, Germany
EAN 2019
Prof. Guido Stoll (University of Würzburg, Germany) reviewed T cell and platelet signalling pathways involved in thrombo-inflammation during ischaemia/reperfusion (I/R), and also discussed clinical trials targeting acute stroke-related inflammation [1]. Ischaemic stroke elicits a strong neuroinflammatory response in the acute and chronic stage, according to Prof. Stoll. However, the functional relevance and therapeutic potential of neuroinflammation have only recently become apparent. T cells contribute to ischaemia–reperfusion injury after recanalization in an antigen-independent manner. “Surprisingly, the detrimental T cell effects are platelet-dependent. Glycoprotein (GP)Ib-mediated and GPVI-mediated platelet activation, but not GPIIb–IIIa-mediated platelet aggregation, is an important checkpoint that orchestrates thrombotic and pro-inflammatory pathways. Downstream activation of coagulation factor XII is a driving force of ischaemia–reperfusion injury ...

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