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Haematoma expansion and mortality in intracerebral haemorrhage after OAC

Conference
EAN 2019
Results of a meta-analysis show that in patients with intracerebral haemorrhage (ICH), use of vitamin K antagonists (VKA) leads to larger haematoma volume, increased rate of secondary haematoma expansion (HE), and higher mortality compared with non-vitamin K antagonist oral anticoagulants (NOACs) or not using oral anticoagulants (non-OACs) [1]. In this systematic review and meta-analysis, a total of 19 studies with data on 16,546 ICH patients using VKA and 128,561 ICH patients using non-OACs were included; moreover, 2 studies reported data on 4,943 ICH patients using NOACs. Results showed that haematoma volume was significantly larger in VKA-users (mean difference vs non-OACs-users of +9.66 mL; P<0.001) and HE occurred significantly more often in VKA-users than in non-OACs-users (OR 2.96; 95% CI 1.74-4.97; P<0.001). The risk of in-hospital mortality (OR 1.83, 95% CI 1.61-2.07; P<0.001) and 3-months mortality (OR 2.24; 95% CI 1.52-3.31; P<...


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