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Apixaban superior to VKAs for major bleeding, stroke/STE and all-cause mortality


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Conference
ESC 2019
Trial
NAXOS
A French observational study comparing different types of non-vitamin K oral anticoagulation (NOAC) showed that 42% to 65% of patients were treated with standard doses of these agents. Analyses of standard doses confirmed the superiority of apixaban when compared to vitamin K antagonists (VKAs) for major bleeding, stroke, and all-cause mortality. Real-world data which compares all currently available NOACs on a nationwide scale are not available. As NOACs are often underdosed in everyday practice, comparing the different agents can be rather complicated. NAXOS, a French real-world study, compared safety (major bleeding), effectiveness (stroke, systemic thromboembolic events [STE]) and all-cause mortality for the NOACs apixaban, dabigatran, rivaroxaban, and VKAs, in adult patients with non-valvular atrial fibrillation (NVAF) who initiated a given NOAC between 2014 and 2016. Analyses were performed with adjustment on propensity scores. To avoid bias potentia...


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