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New treatment may reverse coeliac disease

Presented By
Prof. Ciarán Kelly, Harvard Medical School, USA

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Conference
UEGW 2019
A phase 2a clinical trial demonstrated the proof-of-principle that it is possible to induce immune tolerance to gluten in individuals with coeliac disease. After treatment with investigational drug CNP-101, patients were able to eat gluten with a substantial reduction in inflammation. Prof. Ciarán Kelly (Harvard Medical School, USA) presented the initial results from the randomised, double-blind, placebo-controlled phase 2a trial which tested CNP-101 8 mg/kg vs placebo in 34 adult coeliac disease patients, assessing the markers of potential efficacy and safety [1]. At inclusion, patients had well-controlled, biopsy-proven coeliac disease, and after inclusion they underwent an oral gluten challenge. Treatments were administered intravenously on day 1 and day 8. The gluten challenge began 7 days after the second treatment administration and included 12 grams of gluten per day for 3 days followed by 6 grams of gluten per day for 11 days. The primary en...


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