Home > Haematology > ASH 2019 > Plenary Scientific Session > Experimental model for limitations of haematopoietic stem cells propagation

Experimental model for limitations of haematopoietic stem cells propagation

Presented By
Dr Jennifer Myers SanMiguel, The Jackson Laboratory, USA
Conference
ASH 2019
Dr Jennifer Myers SanMiguel (The Jackson Laboratory, USA) presented a novel mechanism of cell-extrinsic stressors emerging from the ageing bone marrow microenvironment in promoting Dnmt3a-mutant clonal haematopoiesis [1]. The knowledge gap that Dr SanMiguel and colleagues attempted to address was how self-renewal of somatic stem cells such as haematopoietic stem cells (HSCs) are limited in their repopulation ability. A molecular clue from several studies point to DNA methylase DNA (cytosine-5)-methyltransferase 3A (Dnmt3a). Loss of the Dnmt3a gene removes self-renewal limits allowing indefinite HSC propagation in vivo. Dr SanMiguel and colleagues examined the role of HSC-extrinsic stressors in overcoming the impaired differentiation of Dnmt3a-mutant HSCs. Using bone marrow from young Dnmt3aR878H/+ mice into young and old congenic recipient mice, she noted an accelerated expans...


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