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Home > Haematology > EHA 2021 > Leukaemia > Fixed 12 cycles and MRD-guided venetoclax consolidation effective in CLL

Fixed 12 cycles and MRD-guided venetoclax consolidation effective in CLL

Presented By
Dr Mark-David Levin, Albert Schweitzer Hospital, the Netherlands
Conference
EHA 2021
Trial
Phase 2, HOVON 139/GiVe
Primary endpoint results of the phase 2 HOVON 139/GiVe trial demonstrated high efficacy and good tolerability after fixed 12 cycles of venetoclax or minimal residual disease (MRD)-guided treatment with venetoclax after pre-induction with obinutuzumab. These results warrant further research on both these treatment options for patients with naĂŻve chronic lymphocytic leukaemia (CLL) who are unfit for first-line fludarabine, cyclophosphamide, and rituximab (FCR). Fixed-duration treatment of CLL patients with venetoclax combined with anti-CD20 antibody, both in first-line (12 cycles) and in relapsed/refractory (r/r) disease (24 cycles) results in high rates of undetectable MRD and prolonged progression-free survival (PFS) [1]. The randomised, phase 2 HOVON 139/GiVe trial enrolled CLL patients who were unfit for first-line FCR. The trial evaluated the impact of a standard or MRD-based addition of venetoclax for 12 cycles after induction treatment with ...


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