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Diagnosing cardiac sarcoidosis with endomyocardial biopsies

ACC 2019
Diagnosing cardiac sarcoidosis can be a real challenge due to the relative rareness of the disease, as well as symptoms that are often vague and easily attributed to other conditions. In diagnosing cardiac sarcoidosis, endomyocardial biopsies could be of great use, and its yield can be significantly improved with appropriate use of imaging studies and electrophysiology mapping. The Expert Consensus Recommendations on Criteria for the Diagnosis of Cardiac Sarcoidosis mentions two ways of diagnosing cardiac sarcoidosis: 1) by diagnosing the presence of non-caseating granuloma on histological examination of myocardial tissue with no alternative cause, and 2) clinical diagnosis from invasive and non-invasive studies [1]. However, the disease’s patchy myocardial involvement limits the diagnostic yield of blind endomyocardial biopsies. Granrud et al. presented the case of a 47-year-old Caucasian female with a longstanding history of atypical chest pain [2...

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