Home > Cardiology > ACC 2021 > Therapeutic anticoagulation inferior to prophylactic anticoagulation in COVID-19

Therapeutic anticoagulation inferior to prophylactic anticoagulation in COVID-19

Presented By
Prof. Renato Lopes, Duke University, USA

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Conference
ACC 2021
Trial
ACTION
Rivaroxaban did not demonstrate improved clinical outcomes when compared with in-hospital prophylactic anticoagulation in patients who were hospitalised with COVID-19 and had elevated D-dimer levels. Furthermore, those treated with rivaroxaban showed increased rates of bleeding compared with those receiving prophylactic anticoagulation in the ACTION trial [1]. Patients with COVID-19 experience frequent venous and arterial thromboembolisms. Elevated levels of D-dimer, a thrombotic biomarker, are harbingers of poorer clinical outcomes (i.e. disease progression and mortality.) Data regarding type, dosage, and duration of an anticoagulation strategy is needed. Prof. Renato Lopes (Duke University Medical Center, USA) presented the ACTION Coalition trial (NCT04394377), which was designed to investigate the effectiveness of a full anticoagulation strategy as compared with a prophylactic anticoag...


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