Home > Cardiology > AHA 2019 > New Frontiers in Lipid Therapy > Targeting LDL-C <70 mg/dL is better than 100 mg/dL after stroke

Targeting LDL-C <70 mg/dL is better than 100 mg/dL after stroke

Presented By
Prof. Pierre Amarenco, Xavier Bichat Medical School and Denis Diderot University, France
Conference
AHA 2019
Trial
Treat Stroke to Target
A large trial evaluated the reduction in cardiovascular (CV) events by targeting low-density lipoprotein cholesterol (LDL-C) <70 mg/dL after atherothrombotic ischaemic stroke compared with a target of LDL-C 100 ± 10 mg/dL, concluding that treating to target LDL-c <70 mg/dL confers a lower risk of recurrent ischaemic events. The Treat Stroke to Target trial 3.5-year follow-up data were presented by Prof. Pierre Amarenco (Xavier Bichat Medical School and Denis Diderot University, France) [1]. This open-label trial randomised patients who had had an atherothrombotic ischaemic stroke in the past 3 months or a transient ischaemic attack (TIA) in the past 15 days (n=2,860) to either a LDL-C target of <70 mg/dL or a target of 100 mg/dL (±10 mg/dL) using statins and/or other lipid lowering therapy (e.g. ezetimibe). The primary endpoint was a composite of is...


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