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Equal benefits of early rhythm control in AF subtypes

Presented By
Dr Andreas Goette, St. Vincenz Hospital Paderborn, Germany

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Conference
AHA 2021
Trial
EAST-AFNET 4
In a prespecified analysis of the EAST-AFNET 4 trial, early rhythm control showed similar clinical benefits for patients with first-diagnosed atrial fibrillation (AF), patients with persistent AF, and patients with paroxysmal AF. However, patients with first-diagnosed AF demonstrated higher hospitalisation rates than patients with paroxysmal or persistent AF when they were randomised to early rhythm-control therapy. The multicentre, investigator-initiated EAST-AFNET 4 trial (NCT01288352) was conducted to assess the benefits of early rhythm-control therapy compared with usual care in patients with early, recently diagnosed AF [1]. Patients with a CHA₂DS₂-VASc score of ≥2 and recent onset (≤1 year) AF were eligible for randomisation. The primary outcome was a composite of cardiovascular death, stroke, heart failure worsening, or acute coronary syndrome. The pr...


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