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Head-to-head: Efficacy of dabigatran versus warfarin on cognitive impairment

Presented By
Prof. Bruno Caramelli, University of São Paulo, Brazil

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Conference
AHA 2021
Trial
Phase 4, GIRAF
Dabigatran treatment in older patients with atrial fibrillation (AF) or atrial flutter did not result in different cognitive outcomes than warfarin treatment after 2 years, as demonstrated in the phase 4 GIRAF trial [1]. AF is associated with cognitive impairment. A recent, retrospective, observational study suggested that anticoagulants may reduce cognitive impairment and dementia in patients with AF [2]. Prof. Bruno Caramelli (University of São Paulo, Brazil) and colleagues conducted a head-to-head comparison of 2 anticoagulants, dabigatran and warfarin, on cognitive outcomes in older patients with AF. The open-label GIRAF trial (NCT01994265) included 200 patients >70 years without major cerebrovascular comorbidities, who were randomised 1:1 to dabigatran (110/150 mg, twice daily) or warfarin (target INR 2-3, once daily). The primary clinical endpoint w...


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