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AI could help detect early heart transplant rejection


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Journal
Nature Medicine
Reuters Health - 28/03/2022 - A novel artificial intelligence (AI) system helped detect early signs and severity of heart transplant rejection in a proof-of-concept study. "Endomyocardial biopsy (EMB) screening represents the standard of care for detecting allograft rejections after heart transplant," Dr. Faisal Mahmood of Brigham and Women's Hospital in Boston and colleagues note in Nature Medicine. "Manual interpretation of EMBs is affected by substantial interobserver and intraobserver variability, which often leads to inappropriate treatment with immunosuppressive drugs, unnecessary follow-up biopsies and poor transplant outcomes." The new AI system, called Cardiac Rejection Assessment Neural Estimator (CRANE), is designed to be used in tandem with clinical assessments to establish an accurate diagnosis quickly and reduce disagreements regarding the presence and severity of rejection. "The model we present is just the first step towards showing that AI-dr...


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