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Atrial shunt device does not improve outcomes in HFpEF


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Journal
The Lancet
Reuters Health - 14/02/2022 - Placing an atrial shunt device does not appear to reduce heart failure rates or improve the health of patients with heart failure and ejection fraction of 40% or higher, a large industry-sponsored randomized controlled trial finds. "In patients with heart failure and preserved ejection fraction (HFpEF), treatment with an atrial shunt device, which is able to dynamically decompress the overloaded left atrium and reduce left atrial pressure, did not improve health status or reduce heart failure hospitalizations overall," lead study author and principal investigator Dr. Sanjiv J. Shah of Northwestern University Feinberg School of Medicine in Chicago, Illinois, told Reuters Health by email. "However, pre-specified and post-hoc subgroup analyses demonstrated that patients with evidence of dynamic pulmonary vascular disease during exercise did worse with the device, whereas those who had normal pulmonary vascular function during exercise did ...


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