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Bone marrow activation tied to atherosclerosis, metabolic syndrome in seemingly healthy people


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Journal
European Heart Journal
Reuters Health -  29/03/2022 -Bone marrow activation, as shown on whole body vascular imaging, is associated with early atherosclerosis and metabolic syndrome in apparently healthy middle-aged individuals, researchers say. "These results place the bone marrow as a central player in the association between metabolic disorders and atherosclerosis - a mechanism that was previously unknown," Dr. Borja Ibanez of Centro Nacional de Investigaciones Cardiovasculares in Madrid (CNIC) told Reuters Health by email. "What surprised us most is the fact that bone marrow hyperreaction is maximal in the presence of risk factors associated with metabolic syndrome." "While it is speculative at this moment," he said, "we believe that targeting the bone marrow might be a novel therapeutic approach to reduce the massive burden of atherosclerosis in a world where metabolic syndrome - obesity and other factors - is massively growing." Principal investigator Dr. Valentin Fuster, CNI...


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