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DAPA-CKD: Dapagliflozin improves CKD survival ± diabetes

Presented By
Prof. Hiddo Heerspink, University of Groningen, the Netherlands
Conference
ESC 2020
Trial
DAPA-CKD trial
The DAPA-CKD trial found that the sodium glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin reduced worsening kidney function or death from renal or cardiovascular disease by 39% [1]. DAPA-CKD assessed the effects of dapagliflozin on chronic kidney disease (CKD) in patients with and without type 2 diabetes mellitus (T2DM). The reductions of this primary endpoint were 36% and even 50% in patients with and without diabetes, respectively. Previously, the CREDENCE study showed that the SGLT2 inhibitor canagliflozin was associated with a 30% risk reduction in renal decline and cardiovascular and renal death among patients with T2DM [2]. In the DAPA-CKD trial, a third of participants did not have diabetes. This raises the prospect of using dapagliflozin to prevent kidney failure in a new group of patients. Prof. Hiddo Heerspink (University of Groningen, the Netherlands) presented the resu...


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