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Home > Cardiology > HFA 2021 > Late-Breaking Trials > Novel mineralocorticoid receptor antagonist effective irrespective of HF history

Novel mineralocorticoid receptor antagonist effective irrespective of HF history

Presented By
Prof. Gerasimos Filippatos, Attikon University Hospital, Greece
Conference
HFA 2021
Trial
FIDELIO-DKD
A subgroup analysis of the FIDELIO-DKD trial revealed that the investigative mineralocorticoid receptor antagonist finerenone improved cardiovascular and kidney outcomes irrespective of a pre-existing heart failure status. In addition, finerenone had a reassuring safety profile. Chronic kidney disease (CKD) and type 2 diabetes (T2D) are highly prevalent among patients with heart failure (HF), and patients suffering from all 3 conditions have an unfavourable prognosis [1–4]. In patients with HF with reduced ejection fraction (HFrEF), guidelines recommend therapy with a steroidal mineralocorticoid receptor antagonist (MRA). However, up to now, a treatment benefit has not been demonstrated in patients with HF and preserved ejection fraction (HFpEF). Finerenone is a novel, selective, non-steroidal MRA that blocks overactivation of the mineralocorticoid receptor. The latter contributes to inflammation and fibrosis, which are both key drivers of CKD in T2...


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