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High-dose flu shots have no added benefit for reducing deaths, hospitalizations in heart patients


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Journal
JAMA
Reuters Health - 10/12/2020 - High-dose influenza vaccine is not more effective than a standard-dose formulation for preventing cardiopulmonary hospitalization and all-cause mortality in high-risk cardiovascular-disease patients, new findings show. "For this particular endpoint we didn't see a difference," Dr. Scott D. Solomon of Brigham and Women's Hospital and Harvard Medical School, in Boston, told Reuters Health by phone. "It may very well be that any formulation of the vaccine is better than nothing at all." The U.S. Centers for Disease Control and Prevention (CDC) recommends annual flu shots for everyone six months of age and older. People with cardiovascular disease (CVD) are at greater risk of complications from flu and adverse outcomes, Dr. Solomon and his colleagues note in JAMA, and have a weaker humoral immune response to standard-dose influenza vaccine than their CVD-free peers. To investigate whether high-dose influenza vaccine, approved for adu...


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