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Race, sex affect NT-proBNP levels when assessing heart failure risk

Journal
JAMA Cardiology
Reuters Health - 03/05/2022 - The absolute risk of heart failure (HF) associated with a given NT-proBNP volume varied substantially by sex and race in a cohort study. Therefore, applying proBNP cut points regardless of sex and race could lead to an underestimation of risk in Black men and an overestimate in white women, researchers say. "NT-proBNP has been known to be lower in men compared to women, and lower in those identifying as Black race compared to White race," Dr. Amil Shah of Brigham and Women's Hospital in Boston told Reuters Health by email. "However, the risk of HF is generally higher in men and higher in Black individuals. Despite these differences, guideline-recommended thresholds for defining heart failure risk and heart failure vary by age but not sex or race." "The main finding from our study was that, at any given NT-proBNP concentration, the absolute risk of developing HF varied substantially between groups defined by race and sex." ...


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