Home > Dermatology > EADV 2019 > Spotlight on Psoriasis > Relationship psoriasis and NAFLD: new data on the hepato-dermal axis

Relationship psoriasis and NAFLD: new data on the hepato-dermal axis

Presented By
Dr Daniel Nieto, La Paz Hospital, Spain
Conference
EADV 2019
A Spanish study showed for the first time that more severe hepatic damage is evident in patients with both psoriasis and non-alcoholic fatty liver disease (NAFLD) [1]. Over the past 10 years, it has become increasingly evident that NAFLD is a multisystemic disease that affects extra-hepatic organ systems and interacts with the regulation of several metabolic and immunological pathways [2]. The prevalence of NAFLD (diagnosed by imaging or by histology) is remarkably higher in psoriatic patients, occurring in up to 50% of patients [2]. Of note, this association is evident even after adjusting for metabolic syndrome traits or other potential confounders. Up to now, no reports on a possible link between the severity of both conditions have been published. To explore a possible association, a total of 64 male patients were included in a prospective 12-month study. Inclusion criteria were NAFLD (histologic steatosis >5%, sonographic steatosis >48 dB...


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