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Novel inflammatory marker improves prognostication in epidermal necrolysis


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Journal
JAMA Dermatology
Reuters Health - 28/12/2021 - Among Asian adults with epidermal necrolysis, RDW/Hb (red cell distribution width to hemoglobin ratio) was strongly predictive of in-hospital mortality and bacteremia, with similar discrimination to the commonly used risk stratifier, Severity-of-Illness Score for Toxic Epidermal Necrolysis (SCORTEN), researchers say. When added to SCORTEN, RDW/Hb improved the predictive accuracy of the composite score, resulting in a proposed revision of SCORTEN (Re-SCORTEN). "We were surprised and excited that RDW/hb, which is derived from the full blood count, is useful as a prognostic marker and its performance is similar to existing prognostic scores, such as SCORTEN," Dr. Haur Yueh Lee of Singapore General Hospital told Reuters Health by email. "These findings need to be validated in other cohorts, and if similar results are shown, we can incorporate that into routine practice." As reported in JAMA Dermatology, the retrospective study includ...


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