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Corticosteroids improve histologic response rates in pediatric eosinophilic esophagitis


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Journal
Pediatrics
Reuters Health - 28/10/2020 - Corticosteroids significantly improve histologic response rates in children with eosinophilic esophagitis (EoE), according to a new meta-analysis. "Our reviews support the use of corticosteroids, but more research needs to be performed, including other therapies, especially the exclusion diet (closely monitored by a physician to avoid unnecessary dietary restrictions)," Dr. Juan Cristobal Gana of Escuela de Medicina, Pontificia Universidad Catolica de Chile, in Santiago, told Reuters Health by email. The mainstays of treatment of EoE include a diet that excludes wheat, milk, egg, nuts, soy, fish and shellfish and pharmacologic measures including topical corticosteroids, which decrease esophageal infiltration by eosinophils, mast cells and lymphocytes. Randomized clinical trials of corticosteroids, however, have yielded inconclusive results. Dr. Gana and colleagues assessed the benefits and harms of corticosteroids versus placebo ...


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