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Similar results for different corticosteroid tapering protocols in UC - Medical Conferences

Home > Gastroenterology > ECCO 2022 > Specific Therapeutic Strategies > Similar results for different corticosteroid tapering protocols in UC

Similar results for different corticosteroid tapering protocols in UC

Presented By
Ms Pernille Ovesen, Herlev University Hospital, Denmark
Conference
ECCO 2022
Trial
SCOTCH
Different prednisolone tapering algorithms did not affect the short-term or long-term effectiveness of infliximab in participants with ulcerative colitis (UC). However, subgroup analysis showed participants with acute severe UC may benefit from standard tapering compared with fast tapering or direct discontinuation of corticosteroids. Corticosteroids are administered in more than 50% of the patients with UC in the first 5 years after diagnosis [1]. In patients with acute severe UC, corticosteroids are often administered in combination with TNF inhibitors. However, data is limited on the role of corticosteroid tapering in this population. The current, retrospective, single-centre study investigated the impact of prednisolone tapering algorithms on the short-term and long-term effectiveness of infliximab in patients with UC [2]. Participants were categorised according to the following tapering protocol: standard (≤5 mg/week; n=42), fast (>5 mg/w...


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