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Fecal transplant stops beta cell decline in newly diagnosed T1D


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Journal
Gut
Reuters Health - 20/11/2020 - Fecal microbiota transplantation (FMT) stops the functional decline of islet beta cells in adults with new-onset type-1 diabetes (T1D), a new randomized controlled trial shows. "Autoimmune diseases could be fueled by altered (small) intestinal gut microbiota composition," Dr. Max Niewdorp of Amsterdam University Medical Centres, in the Netherlands, told Reuters Health by email. "Diet and gut microbiota composition could be important in autoimmune endocrine diseases, but more research is needed." Studies in mice suggest that T1D is associated with changes in the microbiome, and that the small-intestinal immune system may play a role, Dr. Niewdorp and his team write in Gut. They investigated whether autologous FMTs or allogeneic FMTs from healthy donors would affect beta-cell function in 20 patients with diabetes diagnosed less than six weeks previously. Patients were randomized to receive three donor FMTs or three autologous FMTs ...


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