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Greater intestinal permeability seen with bile acid diarrhea than IBS diarrhea


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Journal
Gastroenterology
Reuters Health - 30/12/2021 - People with bile acid diarrhea (BAD) may have more permeable intestines than people with irritable bowel syndrome diarrhea (IBS-D), a new study suggests. "This study shows for the first time that patients with biochemically proven BAD have greater intestinal permeability (measured by validated non-invasive testing) than patients with IBS-diarrhea, reinforcing the need to positively diagnose and specifically treat BAD," Dr. Michael Camilleri of Mayo Clinic in Rochester, Minnesota, told Reuters Health by email. "Among patients with IBS-D, about 30% have increased hepatic synthesis or malabsorption of bile acids, resulting in increased colonic bile acid concentrations," he explained. "It is well established that some bile acids cause colonic secretion and stimulate colonic motility. This reduced barrier function may predispose to further water and electrolyte secretion or facilitate mucosal inflammation." Dr. Camilleri and his colle...


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