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Impact of strategies on intestinal resection rate

Presented By
Dr D. Ley, University of Wisconsin–Madison, USA
ECCO 2020
A population-based cohort study in paediatric-onset inflammatory bowel disease (IBD) patients looked at the impact of therapeutic strategies on intestinal resection rate over a period of 24 years [1]. In parallel with the increased use of immunosuppressants and anti-TNF agents, resection rate within 5 years after diagnosis decreased in paediatric Crohn’s disease (CD). Children with IBD of 16 years and younger between 1988 and 2011 were drawn from a prospective French study and were retrospectively followed until 2013. Three diagnostic periods were distinguished: 1988–1993 (P1), 1994–2000 (P2), and 2001–2011 (P3). Risks for intestinal resection, hospitalisation, and complicated CD behaviour (stricturing or penetrating) were assessed and compared 5 years after diagnosis. A total of 800 patients with CD and 261 with ulcerative colitis (UC) were followed up for a median of 8.9 years. Exactly half of them (n=531) were boys; median age at diagnosis was 14.3 year...

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