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Liquid biopsy might help detect, manage liver cancer in the future


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Journal
Gut
Reuters Health - 21/09/2020 - Liquid biopsy could someday be useful for the early detection and clinical management of hepatocellular carcinoma (HCC), according to a new review. Currently, there are no highly accurate methods for early detection of HCC and no biomarkers to identify patients who will benefit from combination therapy. In a report in Gut, Dr. Johann von Felden of Universitaetsklinikum Hamburg-Eppendorf, in Hamburg, Germany and colleagues summarize recent developments in liquid biopsy and its potential application in the clinical management of HCC. The usefulness of liquid biopsy relies on the release and molecular analysis of tumor components in the bloodstream or other body fluids. These components include nucleic acids, circulating tumor cells (CTCs), and extracellular vesicles (EVs), which are membrane-embedded nanovesicles actively released by all cell types that function in cell-to-cell communication. Methylation profiling from plasm...


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