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Nanogels boost therapeutic response in resistant pancreatic cancer in mice


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Journal
Gut
Reuters Health - 30/12/2021 - In mice with pancreatic ductal adenocarcinoma (PDAC), nanogels containing nitric oxide (NO) and TRAIL (tumor necrosis factor -related apoptosis-inducing ligand) increased TRAIL delivery to tumors and overcame resistance to therapy. Stromal barriers, such as the desmoplastic stroma that is characteristic of PDAC, can block the delivery and decrease the tumor-penetrating ability of therapeutics such as TRAIL, which selectively induces cancer cell death, researchers explain in Gut. Dr. Yunching Chen of National Tsing Hua University in Taiwan and colleagues aimed to develop a TRAIL-based nanotherapy that not only eliminated the extracellular matrix barrier to increase TRAIL delivery into tumors, but also blocked antiapoptotic mechanisms to overcome TRAIL resistance in PDAC. They theorized that since NO plays a role in preventing tissue desmoplasia, if it could be delivered together with TRAIL, it might improve TRAIL delivery to tumor...


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