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New PROM for Crohn’s perianal fistula has clinical, research potential


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Reuters Health - 05/01/2021 - A draft patient-reported outcome measure (PROM) questionnaire for Crohn's perianal fistula may be useful for shaping both research and clinical practice, a recent study suggests. Researchers developed a 28-item PROM questionnaire for Crohn's perianal fistula and tested it with 211 patients living with this condition. An evaluation of patients' responses to the questionnaire found the PROM, called the Crohn's Anal Fistula Quality of Life (CAF-QoL), had good stability (interclass correlation alpha 0.98) and internal consistency (Cronbach's alpha 0.88) as well as construct validity and good responsiveness. "This new PROM lends itself to utility in clinical trial design for Crohn's perianal fistulas, enabling consistency in data sets collected in this condition," said lead study author Samuel Adegbola of Imperial College London in the UK. "It also has the potential utility of assessment of disease impact in a clinic setting, to guide...


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