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Possible causal link between eosinophilic inflammation and anxiety

Presented By
Dr Jukka Ronkainen, Course Health Research, Finland
UEGW 2020
After a 10-year follow-up, anxiety at baseline was independently associated with a 15-fold increased risk of eosinophilia, while anxiety at follow-up was associated with a 5-fold increased risk with duodenal eosinophilia [1]. A prospective population-based study from Sweden demonstrated for the first time a possible causal link between duodenal inflammation and psychological distress in a functional gut disorder. Functional dyspepsia is a distressing, frequent disorder with a prevalence of approximately 15% in the general population. Anxiety was found to be strongly associated with new-onset functional dyspepsia. In addition, increased duodenal eosinophil counts have been observed in patients with functional dyspepsia. Gut symptoms may precede the development of anxiety in patients with a functional gut disorder. However, the underlying mechanisms are unknown. Duodenal eosinophilia is a potential cause of anxiety. Population-based study from...

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