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Probiotic provides a potential adjuvant treatment to gluten-free diet

Presented By
Ms Britt Otten, Maastricht University, the Netherlands
UEGW 2020
In the duodenum of patients with celiac disease, the expression of the human serine protease inhibitor elafin is decreased. The appearance of the probiotic Bifidobacterium longum NCC2705 in duodenal aspirates was associated with a simultaneous increase in the concentration of serpin, a bacterial homologue of elafin, in patients with celiac disease or non-celiac gluten sensitivity [1]. Celiac disease is a chronic autoimmune enteropathy triggered by gluten ingestion. Non-celiac gluten sensitivity is an emerging symptom-based condition, triggered by the ingestion of wheat and related cereals, but in the absence of celiac disease or wheat allergy. The standard treatment of these 2 conditions is a gluten-free diet. However, adherence to a strict gluten-free diet is challenging due to accidental gluten intake. In a previous mouse model of celiac disease, B. longum NCC2705 was shown to ameliorate gluten immunopathology t...

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