Home > Haematology > ASH 2019 > Sickle Cell Disease > Arginine supplements help against sickle cell disease pain

Arginine supplements help against sickle cell disease pain

Presented By
Prof. Richard Onalo, University of Abuja, Nigeria
ASH 2019
New findings indicate that oral arginine serves as a beneficial and widely accessible adjuvant therapy for children with sickle cell anaemia and vaso-occlusive pain episodes [1]. Prof. Richard Onalo (University of Abuja, Nigeria) presented a double-blind, randomised, placebo-controlled trial that investigated the opioid-sparing effects of 100 mg/kg oral L-arginine in the amelioration of severe vaso-occlusive pain episodes (VOE) versus placebo in paediatric patients in sub-Saharan Africa with sickle cell anaemia. Children with sickle cell anaemia (n=68; ages 5-17), scoring at least a 7 of 10 on the Numerical Pain Scale Score (NPRS), received either arginine (n=35) or placebo (n=33) every 8 hours for up to 5 days or 15 doses. Baseline characteristics, including pain scores, were similar between treatment arms. Physicians obtained information including patient demographics, clinical characteristics, length of hospital stay, pain scores, time-to-crisis resolut...

Please login to read the full text of the article.

If you have no account yet, please register now.

Posted on