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Arginine supplements help against sickle cell disease pain

Presented By
Prof. Richard Onalo, University of Abuja, Nigeria
Conference
ASH 2019
New findings indicate that oral arginine serves as a beneficial and widely accessible adjuvant therapy for children with sickle cell anaemia and vaso-occlusive pain episodes [1]. Prof. Richard Onalo (University of Abuja, Nigeria) presented a double-blind, randomised, placebo-controlled trial that investigated the opioid-sparing effects of 100 mg/kg oral L-arginine in the amelioration of severe vaso-occlusive pain episodes (VOE) versus placebo in paediatric patients in sub-Saharan Africa with sickle cell anaemia. Children with sickle cell anaemia (n=68; ages 5-17), scoring at least a 7 of 10 on the Numerical Pain Scale Score (NPRS), received either arginine (n=35) or placebo (n=33) every 8 hours for up to 5 days or 15 doses. Baseline characteristics, including pain scores, were similar between treatment arms. Physicians obtained information including patient demographics, clinical characteristics, length of hospital stay, pain scores, time-to-crisis resolut...


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