Home > Haematology > ASH 2019 > Plenary Scientific Session > Erythroferrone and skeletal changes associated with thalassaemia

Erythroferrone and skeletal changes associated with thalassaemia

Presented By
Dr Melanie Castro-Mollo, Icahn School of Medicine at Mount Sinai, USA
Conference
ASH 2019
Dr Melanie Castro-Mollo (Icahn School of Medicine at Mount Sinai, USA) presented her team’s research into the molecular mechanism for the skeletal changes associated with thalassaemia [1]. Patients with β-thalassaemia are known to have low bone mass due to decreased mineral density and cortical thinning, but the role of erythroferrone (ERFE) in causing these changes was unknown. ERFE suppresses hepcidin via the sequestration of bone morphogenetic proteins (BMPs)—positive regulators of hepcidin via its interaction with haemojuvelin. ERFE is produced by erythroblasts, thereby increasing iron availability for haematopoiesis as the inhibition by hepcidin on iron absorption is removed. Dr Castro-Mollo described how BMPs are also produced by osteoblasts to varying degrees throughout their maturation process, at even higher levels than those produced by erythroblasts. This discovery led to the hypothesis that ERFE regulates bone formation and remodelling. ...


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