Home > Haematology > ASH 2020 > Acute Lymphoblastic Leukaemia > Encouraging outcomes after autoHCT in patients with ALL

Encouraging outcomes after autoHCT in patients with ALL

Presented By
Prof. Sebastian Giebel, Maria Skłodowska-Curie National Research Institute of Oncology, Poland

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Conference
ASH 2020
Results of autologous haematopoietic cell transplantation (autoHCT) for patients with acute lymphoblastic leukaemia (ALL) aged >55 years in first complete remission and with measurable residual disease (MRD)-negativity pre-transplant are encouraging. This option may be a valuable alternative to reduced-intensity conditioning (RIC)-allogeneic HCT and is associated with improved overall survival (OS) compared with transplantations from HLA-matched unrelated donors [1]. Patients with ALL aged >55 years treated with conventional-dose chemotherapy have poor outcomes. Due to the frequent presence of comorbidities, many patients are ineligible for myeloablative allogeneic HCT (alloHCT). The role of autoHCT and RIC-alloHCT is not well-established. The goal of this study was to analyse results of these transplant options and to identify factors affecting outcome. Prof. Sebastian Giebel (Maria Skłodows...


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